LinearFold Web Server (beta)

Interactive demo
Add a sequence Paste or type your sequence here (length < 100,000):

Or upload a file in FASTA format:
Choose File
No file chosen...

Set beam size Beam size (1-200):

Choose model(s)


Preset demo

Example demos for 16S rRNA/23S rRNA/Group I Intron are available, compared with CONTRAfold v2.0 and Vienna RNAfold algorithms.

Please cite the following paper:

* Liang Huang, **He Zhang, **Dezhong Deng, Kai Zhao, Kaibo Liu, David Hendrix, and David H. Mathews (2019). LinearFold: Linear-Time Approximate RNA Folding by 5’-to-3’ Dynamic Programming and Beam Search. Bioinformatics, Volume 35, Issue 14, July 2019, Pages i295–i304. ISMB 2019
*Corresponding Author, **Equal Contribution.

Code: github (implemented by Kai Zhao, Dezhong Deng, He Zhang, and Liang Huang)
Web Demo designed by Kaibo Liu (
Some Other RNA Secondary Structure Prediction Web Servers
RNAfold (Vienna)   RNAstructure (Rochester)   CONTRAfold (Stanford)   Mfold (Albany)   CentroidFold (JBIC)